電針對APP /PS1 轉(zhuǎn)基因AD 小鼠Morris 水迷宮學習記憶行為的影響
(北京中醫(yī)藥大學針灸推拿學院，北京100029)
The Effect of Electro － acupuncture on Learning and Memory Behavior of APP /PS1 Transgenic AD Mice in Morris Water Maze
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摘要 摘要:目的探討電針對5 月齡APP /PS1 轉(zhuǎn)基因阿爾茨海默病(Alzheimer's disease，AD)模型小鼠學習記憶行為學 的影響。方法將16 只APP /PS1 轉(zhuǎn)基因陽性雄鼠隨機分為模型組、電針組，每組各8 只，8 只APP /PS1 轉(zhuǎn)基因陰 性雄小鼠為對照組，電針組針刺“百會”、“涌泉”穴位后接電針儀，疏密波，每次針刺持續(xù)15 min，隔日1 次，對照組、 模型組以相同方法用鼠袋束縛15 min，隔日1 次，3 組都持續(xù)5 周，以Morris 水迷宮檢測小鼠學習記憶能力。結(jié)果 3 組間的鼠逃避潛伏期的差異均有統(tǒng)計學意義(P ＜ 0. 05)，電針組與模型組小鼠之間的差異有統(tǒng)計學意義(P＜0. 05)。結(jié)論電針能提高APP /PS1 轉(zhuǎn)基因AD 模型小鼠的學習記憶能力。
關(guān)鍵詞：電針 APP /PS1 Morris 水迷宮 學習記憶
Abstract： Abstract:Objective To explore the effect of electro-acupuncture on learning and memory behavior of five months APP / PS1 transgenic AD mice． Method 16 APP /PS1 transgenic positive male mice were randomly divided into the model group and the electro-acupuncture group，8 in each group． At the same time，there were 8 APP /PS1 transgenic negative male mice as the normal control group． The“baihui”and“yongquan”of electro-acupuncture group were acupunctured using dilatational wave for 15 min ，every other day at a time． By the same method ，the mice of control and model group were bounded by binder for 15 min． The all three groups were treatmented for five weeks． Finally the ability of learning and memory of all mice was tested by Morris water maze． Ｒesult Escape latency between three groups was statistically significant( P ＜ 0. 05 )，escape latency between the model group and the electro-acupuncture group was statistically significant ( P ＜ 0. 05 ) ． Conclusion Electro-acupuncture can improve learning and memory ability of APP /PS1 transgenic AD mice．
Keywords： electro-acupuneture APP /PS1 Morris water maze test learning and memory behavior
引用本文:
白楊, 辛隨成, 加吾拉, 李芙, 王鑫.電針對APP /PS1 轉(zhuǎn)基因AD 小鼠Morris 水迷宮學習記憶行為的影響[J] 實驗動物科學, 2014,V31(01): 10-14
BAI Yang, XIN Sui-Cheng, JIA Wu-La, LI Fu, WANG Xin.The Effect of Electro － acupuncture on Learning and Memory Behavior of APP /PS1 Transgenic AD Mice in Morris Water Maze[J] laboratory animal science, 2014,V31(01): 10-14
(北京中醫(yī)藥大學針灸推拿學院，北京100029)
The Effect of Electro － acupuncture on Learning and Memory Behavior of APP /PS1 Transgenic AD Mice in Morris Water Maze
Download: PDF (0KB) HTML 1KB Export: BibTeX or EndNote (RIS) Supporting Info
摘要 摘要:目的探討電針對5 月齡APP /PS1 轉(zhuǎn)基因阿爾茨海默病(Alzheimer's disease，AD)模型小鼠學習記憶行為學 的影響。方法將16 只APP /PS1 轉(zhuǎn)基因陽性雄鼠隨機分為模型組、電針組，每組各8 只，8 只APP /PS1 轉(zhuǎn)基因陰 性雄小鼠為對照組，電針組針刺“百會”、“涌泉”穴位后接電針儀，疏密波，每次針刺持續(xù)15 min，隔日1 次，對照組、 模型組以相同方法用鼠袋束縛15 min，隔日1 次，3 組都持續(xù)5 周，以Morris 水迷宮檢測小鼠學習記憶能力。結(jié)果 3 組間的鼠逃避潛伏期的差異均有統(tǒng)計學意義(P ＜ 0. 05)，電針組與模型組小鼠之間的差異有統(tǒng)計學意義(P＜0. 05)。結(jié)論電針能提高APP /PS1 轉(zhuǎn)基因AD 模型小鼠的學習記憶能力。
關(guān)鍵詞：電針 APP /PS1 Morris 水迷宮 學習記憶
Abstract： Abstract:Objective To explore the effect of electro-acupuncture on learning and memory behavior of five months APP / PS1 transgenic AD mice． Method 16 APP /PS1 transgenic positive male mice were randomly divided into the model group and the electro-acupuncture group，8 in each group． At the same time，there were 8 APP /PS1 transgenic negative male mice as the normal control group． The“baihui”and“yongquan”of electro-acupuncture group were acupunctured using dilatational wave for 15 min ，every other day at a time． By the same method ，the mice of control and model group were bounded by binder for 15 min． The all three groups were treatmented for five weeks． Finally the ability of learning and memory of all mice was tested by Morris water maze． Ｒesult Escape latency between three groups was statistically significant( P ＜ 0. 05 )，escape latency between the model group and the electro-acupuncture group was statistically significant ( P ＜ 0. 05 ) ． Conclusion Electro-acupuncture can improve learning and memory ability of APP /PS1 transgenic AD mice．
Keywords： electro-acupuneture APP /PS1 Morris water maze test learning and memory behavior
引用本文:
白楊, 辛隨成, 加吾拉, 李芙, 王鑫.電針對APP /PS1 轉(zhuǎn)基因AD 小鼠Morris 水迷宮學習記憶行為的影響[J] 實驗動物科學, 2014,V31(01): 10-14
BAI Yang, XIN Sui-Cheng, JIA Wu-La, LI Fu, WANG Xin.The Effect of Electro － acupuncture on Learning and Memory Behavior of APP /PS1 Transgenic AD Mice in Morris Water Maze[J] laboratory animal science, 2014,V31(01): 10-14
